Latent Space: The AI Engineer Podcast

Latent.Space 306 - Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: business@latent.space

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Latent Space: The AI Engineer Podcast

Epizode

Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

You are the Team — Anekha Sokhal, Moshi

AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

The Programmable Data Center — Evan Conrad, SF Compute

Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

Academia is for Ambition — Alex Zhang, MIT

Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

Claude Code’s Next Era — Thariq Shihipar, Anthropic

OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

Runway’s WorldPrompt and the Engineering of Real-Time Worlds

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

Humanity’s Last Invention — Richard Socher of Recursive

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

Simulation: the new Scaling Law — Joon Sung Park, Simile AI

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Inside the Model Factory — Eiso Kant, Poolside AI

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

The Professor of Outputmaxxing — Anjney Midha, AMP

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

🔬Scaling Past Informal AI - Carina Hong, Axiom Math

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

GitHub's plan for Agents — Kyle Daigle, GitHub

Why Video Agent models are next — Ethan He, xAI Grok Imagine

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

Giving Agents Computers — Ivan Burazin, Daytona

Railway: The Agent-Native Cloud — Jake Cooper

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony